August 31, 2012

Natural Serotonin Boosters

natural serotonin boostersAh, to be in a good mood and feel great about yourself!  Imagine if you could find a way to achieve those feelings nearly everyday? Well you can with natural serotonin boosters.

Serotonin is a neurotransmitter that improve our mood and controls our appetite. Natural serotonin boosters include tryptophan and 5-Hydroxytryptophan (5-HTP) among others.  Consumption of high quality protein is the key to serotonin production. Thus, vegetarians are at risk for developing a serotonin deficiency.

The Happy Hormone

Serotonin is sometimes known as the “happy hormone”.  Low levels of serotonin are associated with the glass is half-empty attitude, depression, increased appetite, PMS, dislike for hot and/or dark weather, worry and anxiousness, irritability, panic attacks, and difficulty sleeping.

Serotonin and Obesity

Satiety occurs when serotonin levels are optimal. Though protein is essential for serotonin production, serotonin deficiency leads to carbohydrate cravings which do raise serotonin but lead to excessive weight gain in the form of fat as insulin levels rise in response to carbohydrates.  Binging on carbohydrates is the body’s way of telling you it’s low in serotonin.

Why does eating carbs increase serotonin? Tyrptophan, an amino acid and precursor of serotonin, competes with other amino acids to be transported into the brain.  Carbohydrates stimulate the production of insulin causing muscles to take up the other amino acids leaving tryptophan free to enter the brain and produce serotonin.

Why Does Serotonin Become Low?

Serotonin levels decline for several reasons. Serotonin levels decline with age.  Stress is a huge drain on our serotonin “reserves”. Any type of inflammatory process produces cytokines which degrades tyrptophan leading to lower serotonin levels.

Depression is associated with many inflammatory diseases.  Degradation of tryptophan may provide an answer to that relationship.

But, the biggest reason is probably nutritional. Intake of adequate amounts of tryptophan from the diet are lacking in many suffering from low serotonin levels. Plus, tryptophan is the least abundant amino acid in the diet in part because of the corn-feeding of animals.

Some nutrients rob our bodies of serotonin and include caffeine, ephedrine, mu huang, diet pills, and other stimulants. Another enemy is aspartame or NutraSweet®. Deficiencies in calcium, magnesium, vitamin D, and the B vitamins also limit the production of serotonin and the other neurotransmitters.

Another culprit of low serotonin – lack of sunlight especially between November to February in the northern latitudes. Vitamin D is a co-factor in the production of serotonin. Adequate Vitamin D can offset the lack of sunlight for some sufferers.

Natural Serotonin Boosters: Foods

Tryptophan is an essential amino acid, which means the body cannot synthesize it on its own. It is the key nutrient in natural serotonin booster foods. The best sources of tryptophan are:

  • turkey
  • meat
  • peanuts
  • brown rice
  • sesame seeds
  • bananas
  • cottage cheese and other milk products

Be sure to include these serotonin food boosters in your diet. Consume meats/poultry that have been grass-fed rather than corn-fed as they contain higher levels of tryptophan.

Tryptophan can also be taken in the form of a supplement. Doses of 500 to 1500 mg of tryptophan once or twice a day in mid-afternoon and before bed is recommended.

What’s 5-HTP?

Tryptophan gets converted to 5-HTP, which then gets converted to serotonin.  5-HTP is available as a nutritional supplement, and seems more effective than tyrptophan in managing depression.  5-HTP is the immediate precursor of serotonin.  Doses of 50 mg to 400 mg a day in divided doses can be effective for improving sleep, and treating depression and anxiety. Taking it 2 or 3 times a day is important and it’s helpful to take them if/when you have cravings for sweets. High carbohydrate snacks can raise tryptophan levels, but they are full of empty calories and raise insulin levels.

5-HTP has been shown in some studies to raise serotonin levels better than prescriptions medications, the SSRIs. It’s recommended that you take either tryptophan or 5-HTP. You do not need to take both.

What Else Can Be Done to Boost Serotonin Levels?

Other natural serotonin boosters include St. John’s Wort, which is commonly used in Europe to treat depression, and SAM-e. Serotonin gets metabolized to melatonin. Melatonin supplements are effective sleep aids. Melatonin supplements can spare serotonin stores since serotonin does not need to broken down to manufacture melatonin.

Sun exposure and/or use light therapy, and exercise will boost serotonin levels.  Stress reducing techniques like meditation are helpful in raising serotonin levels by lowering cortisol levels.  Vitamin B6 is an important co-factor in the production of serotonin.  Be sure to get 50 mg to 100 mg a day if you suspect low serotonin levels.  See “Anti Aging Vitamins“.

Are there herbal serotonin boosters? You bet. The herb rhodiola may improve memory and learning ability, and regulate mood.  It stimulates serotonin and dopamine.  200 mg to 400 mg day is the recommended dose. Add natural serotonin boosters to your health regimen.

These are the natural ways to increase serotonin.

This article was updated on 7/25/15.

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Dr. Joe Jacko


Dr. Joe is board certified in internal medicine and sports medicine with additional training in hormone replacement therapy and regenerative medicine. He has trained or practiced at leading institutions including the Hughston Clinic, Cooper Clinic, Steadman-Hawkins Clinic of the Carolinas, and Cenegenics. He currently practices in Columbus, Ohio at Grandview Primary Care. Read more about Dr. Joe Jacko

  1. Have you ever considered about including a little bit more than just your articles?
    I mean, what you say is valuable and all. But just imagine if you added
    some great visuals or videos to give your posts more, “pop”!
    Your content is excellent but with pics and clips, this website could
    undeniably be one of the greatest in its niche.
    Wonderful blog!

    1. Thanks,

      The plan is to add short video segments in the near future. The problem right now is manpower. What topics would like to see video and/or graphics and visuals?
      I appreciate your suggestions.

      Dr. Joe

  2. I think that for me, there is some connection between serotonin from sun exposure at different times of the year independent of vitamin D. I am dark skinned so I don’t generate large amounts of vitamin D from sun exposure. But I can tell that in the spring and early summer, the sun has a bigger impact on my mood than at this time of the year.

    1. I suspect the connection between sun and mood goes beyond vitamin D. Just seeing the sun from indoors will put most of us in better moods.

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