February 19, 2011


Yombe (Yohimbe for Erectile dysfunctionYohimbine) is an alkaloid found in the pausinytalia yohimbe. In the form of yohimbine hydrochloride has been used to treat erectile dysfunction. For years this was the first line of defense for most urologist . Presently with the advent of newer drugs in the erectile dysfunction arena, combined  with the fact the it’s efficacy is questionable, it’s use has greatly declined. It continues to be popular in the over the counter supplement world, in other forms,and is touted to be equivalent to some of the more efficacious medications. Other uses have been to increase libido, again results are questionable.


Yohimbine is and alkaloid found in the pausinystalia yohimbe ( West African evergreen) In its original form it was used as an aphrodisiac. Use of the yohimbe bark has variable results secondary to the fact that it has inconsistent concentrations of the alkaloid. It is not until the bark is treated and the alkaloid is  removed that you can quantify the dosage.


Yohimbine is used only in males and should not be used in individuals with the following diseases

  1. Heart disease
  2. Liver disease
  3. Kidney disease
  4. Severe depression


Traditional starting dosage is 5.4mg orally three times a day. Patients should be reassured that increases in erectile function often noted after three weeks of treatment. One should discontinue the drug if they experience increase blood pressure, severe anxiety, insomnia, rapid heart rate or severe irritability and consult their doctor.

Drug interactions

  1. MAO inhibitors
  2. Anti depressants
  3. Anti hypertensives
  4. Dietary supplements

Yohimbine in Females

The research of yohimbine use by females to increase libido is very limited . Much more research is needed to prove its safety and efficacy in females


Due to the fact that the bark from the African evergreen tree (pausinystlia yohimbe) has variable concentrations of yohmbe alkaloid its use in supplements has extremely poor results as opposed to yohimbine hydrochloride ( the prescription form) and its use is not recommended.

Related article:  “Erectile Dysfunction“, “Good Blood Flow Means Better Sex”, and “Male Menopause Symptoms

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Dr. Joe Jacko

Dr. Joe is board certified in internal medicine and sports medicine with additional training in hormone replacement therapy and regenerative medicine. He has trained or practiced at leading institutions including the Hughston Clinic, Cooper Clinic, Steadman-Hawkins Clinic of the Carolinas, and Cenegenics. He currently practices in Columbus, Ohio at Grandview Primary Care. Read more about Dr. Joe Jacko

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