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May 8, 2018

8 Best Anti-aging Peptides and Their Uses

Peptides are molecules that make your skin perform certain functions. They are made of naturally-occurring amino acids that happen to be the building blocks for certain functions of the body. They can help fight against a variety of anti-aging problems and their benefits are remarkable.

Peptides perform specific jobs, so it’s essential to know which anti-aging peptides are best for you, whether you need peptides to protect against future problems, help get rid of wrinkles and fine lines, or heal and firm your skin. Read on to find out everything you need to know about the best anti-aging peptides.

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anti-aging peptides

1. Pentapeptides

As you age, your skin doesn’t regenerate like it used to. Pentapeptides are among the most commonly-used anti-aging peptides and it’s easy to see why. These peptides are multi-faceted and can be found in many supplements and products. Pentapeptides contain a fatty acid and 5 amino acids that work together to give you a more youthful complexion.

How it works: Pentapeptides stimulate the lowest layers of your skin, which boosts your production of hyaluronic acid and collagen. It’s mild-enough to be used on most skin-types and it can help your skin heal faster and reduce the appearance of spots, wrinkles, fine lines, and sags.

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2. Hexapeptides

As the name implies, these type of anti-aging peptides are comprised of chains of 6 amino acids. They are best known for their “botox-like” results and the formula is quite strong. These peptides may not be for everyone, since hexapeptides can have more immediate and long-lasting results. Hexapeptides are considered among the most permanent option for anti-aging peptides.

How it works: Hexapeptides mostly work by relaxing your facial muscles. Unlike others on the list, they do not stimulate certain responses which trigger skin regeneration. The relaxation of your facial muscles can give you an immediate decrease in the appearance of fine lines.

3. Palmitoyl Oligopeptide

This formula is derived from three amino acids that work in two different ways. It is one of the best anti-aging peptides for this reason, since it can protect against future harm and have immediate results on present anti-aging problems. It is specifically-designed to penetrate the deepest layers of your skin.

How it works: Palmitoyl oligopeptide boosts the production of collagen and hyaluronic acid in your skin. It can also protect your skin from the effects of UV-rays, which damage your skin further. These anti-aging peptides are best for prevention and reducing the appearance of fine lines and wrinkles.

4. Copper Peptides

These are considered one of the most-unique anti-aging peptides out there. They are smaller bits of protein that have been bonded with copper. Making these peptides even stranger is the fact that copper is toxic; but not when it’s combined with a peptide chain. When copper combines with peptides, the formula has great anti-aging benefits.

How it works: Copper peptides increase the skin’s ability to regenerate and heal on an extraordinary level. They can help get rid of spots or blemishes, reduce the appearance of wrinkles and fine lines, and firm-up sags. It can be quite strong however, so use these peptides with care.

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5. Palmitoyl Tetrapeptide-7

Palmitoyl tetrapeptide-7 is made of a chain of four amino acids. These amino acids are combined with a fatty acid called palmitic acid that allows the anti-aging peptides to deeply-penetrate the skin. Rather than others on the list that make the skin perform over-time of a certain function, these peptides help keep away certain substances.

How it works: These peptides are ideal in fighting inflammation and swelling; a main culprit of elasticity-loss. Palmitoyl tetrapeptide-7 can help fight against the elements that cause inflammation and should be used in-combination with other peptide formulas.

6. Caprooyl Tetrapeptide-3

Just like the tetrapeptides above, this peptide is made of four amino acids. Unlike the other however, it is derived from a growth factor which is part lipid. This growth-factor is especially handy in helping even the loosest of skin regain its firmness. The lipid makes these anti-aging peptides more stable and faster-pentrating than some others on the list.

How it works: Caprooyl tetrapeptide-3’s main function is to penetrate extremely-deep in the skin to product more collagen. It increases the overall stability of your skin, which allows the collagen to better penetrate the surface of your skin. Consequently, these peptides are ideal for firming your skin and reducing wrinkles.

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7. Palmitoyl Tripeptide-38

This peptide is ideal for reducing wrinkles over-time. It can nourish, hydrate, and smooth the overall appearance of your skin. Palmitoyl tripeptide-38 can show significant benefits for wrinkles, lines, and crow’s feet; without drying out your skin. It is ideal for results that you’ll notice right away, since it provides you with the ultimate hydration.

How does it work: Palmitoyl tripeptide-38 works by rebuilding the collagen and elastin where you need it most. It gives your skin the boost it needs to repair, regenerate, and rebuild all the skin cells that have lost their youthfulness.

8. Pea Peptide

Pea peptides are also known as Pisum Sativum Extract and it’s a botanical anti-enzyme complex that has both antioxidant and anti-wrinkle properties. It is mild-enough for all skin types and can help improve the overall appearance of sags, fine lines, and wrinkles. Many creams that use these anti-aging peptides can increase firmness in about 6 weeks.

How it works: Pea peptides promote the production of collagen, which improves elasticity. It retextures your skin, while also lifting and firming. Pea peptides accelerate the natural function of collagen; reducing the volume and depth of wrinkles.

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Summing Up

Anti-aging peptides contain all the components necessary to boost the health of your skin and fight back against the effects of aging. Whether you’re looking to heal your skin, protect it, or get rid of fine lines, there’s a peptide out there that fits the mold. So take your time in deciding the best option for your skin and as always. Also, be sure to consult your medical care team with any concerns about starting a new skincare regimen.

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Dr. Joe Jacko


Dr. Joe is board certified in internal medicine and sports medicine with additional training in hormone replacement therapy and regenerative medicine. He has trained or practiced at leading institutions including the Hughston Clinic, Cooper Clinic, Steadman-Hawkins Clinic of the Carolinas, and Cenegenics. He currently practices in Columbus, Ohio. Read more about Dr. Joe Jacko

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